MRPL12

From Wikipedia, the free encyclopedia

Mitochondrial ribosomal protein L12

PDB rendering based on 2ftc.

Available structures: 2ftc

Identifiers

Symbol(s)

MRPL12; 5c5-2; L12mt; MGC8610; MRP-L31/34; MRPL7; MRPL7/L12; RPML12

External IDs

OMIM: 602375 MGI: 1926273 HomoloGene: 2212

Gene ontology
Molecular Function:	• RNA binding • structural constituent of ribosome
Cellular Component:	• intracellular • mitochondrion • mitochondrial large ribosomal subunit • ribosome
Biological Process:	• translation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002949 (mRNA)
NP_002940 (protein)

NM_027204 (mRNA)
NP_081480 (protein)

Location

Chr 17: 77.28 - 77.28 Mb

Chr 11: 120.3 - 120.3 Mb

Pubmed search

[1]

[2]

Mitochondrial ribosomal protein L12, also known as MRPL12, is a human gene.^[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.^[1]

[edit] References

^ ^a ^b Entrez Gene: MRPL12 mitochondrial ribosomal protein L12.

[edit] Further reading

Marty L, Fort P (1996). "A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein.". J. Biol. Chem. 271 (19): 11468–76. PMID 8626705.
Marty L, Taviaux S, Fort P (1997). "Expression and human chromosomal localization to 17q25 of the growth-regulated gene encoding the mitochondrial ribosomal protein MRPL12.". Genomics 41 (3): 453–7. doi:10.1006/geno.1997.4691. PMID 9169145.
Graack HR, Bryant ML, O'Brien TW (2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle.". Biochemistry 38 (50): 16569–77. PMID 10600119.
Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1-2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.". J. Biol. Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468–80. PMID 12706105.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Wang Z, Cotney J, Shadel GS (2007). "Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression.". J. Biol. Chem. 282 (17): 12610–8. doi:10.1074/jbc.M700461200. PMID 17337445.