MRPL10

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Mitochondrial ribosomal protein L10
Identifiers
Symbol(s) MRPL10; MGC17973; MRP-L8; RPML8
External IDs MGI: 1333801 HomoloGene: 41665
Orthologs
Human Mouse
Entrez 124995 107732
Ensembl ENSG00000159111 ENSMUSG00000001445
Uniprot Q7Z7H8 Q3TBW2
Refseq NM_145255 (mRNA)
NP_660298 (protein)		 NM_026154 (mRNA)
NP_080430 (protein)
Location Chr 17: 43.26 - 43.26 Mb Chr 11: 96.86 - 96.87 Mb
Pubmed search [1] [2]

Mitochondrial ribosomal protein L10, also known as MRPL10, is a human gene.[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified two transcript variants that encode different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.[1]

[edit] References

  1. ^ a b Entrez Gene: MRPL10 mitochondrial ribosomal protein L10.

[edit] Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wang CC, Kadota M, Nishigaki R, et al. (2004). "Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21.". Biochem. Biophys. Res. Commun. 314 (2): 335-50. PMID 14733910. 
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.". Genomics 81 (5): 468-80. PMID 12706105. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.". J. Biol. Chem. 276 (47): 43958-69. doi:10.1074/jbc.M106510200. PMID 11551941. 
  • Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.". Genomics 77 (1-2): 65-70. doi:10.1006/geno.2001.6622. PMID 11543634. 
  • Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. (1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences.". J. Biol. Chem. 273 (52): 34828-36. PMID 9857009. 
  • Piatyszek MA, Denslow ND, O'Brien TW (1988). "RNA binding proteins of the large subunit of bovine mitochondrial ribosomes.". Nucleic Acids Res. 16 (6): 2565-83. PMID 3129699. 
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