Mre11-Rad50-Nbs1

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Mre11-Rad50-Nbs1 (MRN) is a complex of proteins involved in DNA damage repair in mammals. Nbs1 is referred to as Nibrin. [1] This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. Its activity includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).[2]

[edit] References

  1. ^ Atlas of Genetics and Cytogenetics in Oncology and Haematology - NBS1. Retrieved on 2008-02-12.
  2. ^ eMedicine - Nijmegen Breakage Syndrome. Retrieved on 2008-02-12.
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