MRE11A

From Wikipedia, the free encyclopedia

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Identifiers

MRE11A; ATLD; HNGS1; MRE11; MRE11B

External IDs

OMIM: 600814 MGI: 1100512 HomoloGene: 4083

Gene ontology
Molecular Function:	• single-stranded DNA specific endodeoxyribonuclease activity • DNA binding • double-stranded DNA binding • protein C-terminus binding • 3'-5' exonuclease activity • hydrolase activity • manganese ion binding
Cellular Component:	• nucleus • nucleoplasm
Biological Process:	• regulation of mitotic recombination • double-strand break repair via nonhomologous end joining • telomere maintenance via telomerase • meiosis • meiotic recombination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005590 (mRNA)
NP_005581 (protein)

NM_018736 (mRNA)
NP_061206 (protein)

Location

Chr 11: 93.79 - 93.87 Mb

Chr 9: 14.54 - 14.58 Mb

Pubmed search

[1]

[2]

MRE11 meiotic recombination 11 homolog A (S. cerevisiae), also known as MRE11A, is a human gene.

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[1]

[edit] References

^ Entrez Gene: MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae).

[edit] Further reading

Petrini JH, Walsh ME, DiMare C, et al. (1996). "Isolation and characterization of the human MRE11 homologue.". Genomics 29 (1): 80–6. doi:10.1006/geno.1995.1217. PMID 8530104.
Dolganov GM, Maser RS, Novikov A, et al. (1996). "Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair.". Mol. Cell. Biol. 16 (9): 4832–41. PMID 8756642.
Carney JP, Maser RS, Olivares H, et al. (1998). "The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.". Cell 93 (3): 477–86. PMID 9590181.
Paull TT, Gellert M (1998). "The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.". Mol. Cell 1 (7): 969–79. PMID 9651580.
Trujillo KM, Yuan SS, Lee EY, Sung P (1998). "Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.". J. Biol. Chem. 273 (34): 21447–50. PMID 9705271.
Chamankhah M, Wei YF, Xiao W (1999). "Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.". Gene 225 (1-2): 107–16. PMID 9931460.
Zhong Q, Chen CF, Li S, et al. (1999). "Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.". Science 285 (5428): 747–50. PMID 10426999.
Goedecke W, Eijpe M, Offenberg HH, et al. (1999). "Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis.". Nat. Genet. 23 (2): 194–8. doi:10.1038/13821. PMID 10508516.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806.
Stewart GS, Maser RS, Stankovic T, et al. (2000). "The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder.". Cell 99 (6): 577–87. PMID 10612394.
Wang Y, Cortez D, Yazdi P, et al. (2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.". Genes Dev. 14 (8): 927–39. PMID 10783165.
Gatei M, Young D, Cerosaletti KM, et al. (2000). "ATM-dependent phosphorylation of nibrin in response to radiation exposure.". Nat. Genet. 25 (1): 115–9. doi:10.1038/75508. PMID 10802669.
Zhu XD, Küster B, Mann M, et al. (2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.". Nat. Genet. 25 (3): 347–52. doi:10.1038/77139. PMID 10888888.
de Vries H, Rüegsegger U, Hübner W, et al. (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMID 11060040.
Fukuda T, Sumiyoshi T, Takahashi M, et al. (2001). "Alterations of the double-strand break repair gene MRE11 in cancer.". Cancer Res. 61 (1): 23–6. PMID 11196167.
Desai-Mehta A, Cerosaletti KM, Concannon P (2001). "Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization.". Mol. Cell. Biol. 21 (6): 2184–91. doi:10.1128/MCB.21.6.2184-2191.2001. PMID 11238951.
Paull TT, Cortez D, Bowers B, et al. (2001). "Direct DNA binding by Brca1.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6086–91. doi:10.1073/pnas.111125998. PMID 11353843.
Hopfner KP, Karcher A, Craig L, et al. (2001). "Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase.". Cell 105 (4): 473–85. PMID 11371344.
Pitts SA, Kullar HS, Stankovic T, et al. (2001). "hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay.". Hum. Mol. Genet. 10 (11): 1155–62. PMID 11371508.
Chiba N, Parvin JD (2001). "Redistribution of BRCA1 among four different protein complexes following replication blockage.". J. Biol. Chem. 276 (42): 38549–54. doi:10.1074/jbc.M105227200. PMID 11504724.