MPHOSPH10

From Wikipedia, the free encyclopedia

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)

Identifiers

MPHOSPH10; MPP10; MPP10P

External IDs

OMIM: 605503 MGI: 1915223 HomoloGene: 4229

Gene ontology
Molecular Function:	• protein binding • RNA splicing factor activity, transesterification mechanism
Cellular Component:	• nucleus • nucleolus • small nucleolar ribonucleoprotein complex
Biological Process:	• rRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005791 (mRNA)
NP_005782 (protein)

NM_026483 (mRNA)
NP_080759 (protein)

Location

Chr 2: 71.21 - 71.23 Mb

Chr 7: 64.26 - 64.27 Mb

Pubmed search

[1]

[2]

M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein), also known as MPHOSPH10, is a human gene.^[1]

This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein is thought to be part of the U3 small nucleolar ribonucleoprotein complex, which is involved in rRNA processing.^[1]

[edit] References

^ ^a ^b Entrez Gene: MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein).

[edit] Further reading

Matsumoto-Taniura N, Pirollet F, Monroe R, et al. (1997). "Identification of novel M phase phosphoproteins by expression cloning.". Mol. Biol. Cell 7 (9): 1455–69. PMID 8885239.
Westendorf JM, Konstantinov KN, Wormsley S, et al. (1998). "M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component.". Mol. Biol. Cell 9 (2): 437–49. PMID 9450966.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Granneman S, Gallagher JE, Vogelzangs J, et al. (2003). "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes.". Nucleic Acids Res. 31 (7): 1877–87. PMID 12655004.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.