MPG (gene)

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N-methylpurine-DNA glycosylase
PDB rendering based on 1bnk.
Available structures: 1bnk, 1ewn, 1f4r, 1f6o
Identifiers
Symbol(s) MPG; AAG; APNG; CRA36.1; MDG; Mid1; PIG11; PIG16; anpg
External IDs OMIM: 156565 MGI: 97073 HomoloGene: 1824
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4350 268395
Ensembl ENSG00000103152 ENSMUSG00000020287
Uniprot P29372 Q3U1C9
Refseq NM_001015052 (mRNA)
NP_001015052 (protein)		 NM_010822 (mRNA)
NP_034952 (protein)
Location Chr 16: 0.07 - 0.08 Mb Chr 11: 32.13 - 32.13 Mb
Pubmed search [1] [2]

N-methylpurine-DNA glycosylase, also known as MPG, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: MPG N-methylpurine-DNA glycosylase.

[edit] Further reading

  • Hollis T, Lau A, Ellenberger T (2000). "Structural studies of human alkyladenine glycosylase and E. coli 3-methyladenine glycosylase.". Mutat. Res. 460 (3-4): 201-10. PMID 10946229. 
  • O'Connor TR, Laval J (1991). "Human cDNA expressing a functional DNA glycosylase excising 3-methyladenine and 7-methylguanine.". Biochem. Biophys. Res. Commun. 176 (3): 1170-7. PMID 1645538. 
  • Chakravarti D, Ibeanu GC, Tano K, Mitra S (1991). "Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase.". J. Biol. Chem. 266 (24): 15710-5. PMID 1874728. 
  • Samson L, Derfler B, Boosalis M, Call K (1991). "Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16.". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9127-31. PMID 1924375. 
  • Kielman MF, Smits R, Devi TS, et al. (1993). "Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse.". Mamm. Genome 4 (6): 314-23. PMID 8318735. 
  • Vickers MA, Vyas P, Harris PC, et al. (1993). "Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere.". Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3437-41. PMID 8475094. 
  • Lau AY, Schärer OD, Samson L, et al. (1998). "Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision.". Cell 95 (2): 249-58. PMID 9790531. 
  • Miao F, Bouziane M, Dammann R, et al. (2000). "3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins.". J. Biol. Chem. 275 (37): 28433-8. doi:10.1074/jbc.M001064200. PMID 10854423. 
  • Lau AY, Wyatt MD, Glassner BJ, et al. (2001). "Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG.". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13573-8. doi:10.1073/pnas.97.25.13573. PMID 11106395. 
  • Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339-52. PMID 11157797. 
  • Kim NK, An HJ, Kim HJ, et al. (2002). "Altered expression of the DNA repair protein, N-methylpurine-DNA glycosylase (MPG) in human gonads.". Anticancer Res. 22 (2A): 793-8. PMID 12014652. 
  • Vallur AC, Feller JA, Abner CW, et al. (2002). "Effects of hydrogen bonding within a damaged base pair on the activity of wild type and DNA-intercalating mutants of human alkyladenine DNA glycosylase.". J. Biol. Chem. 277 (35): 31673-8. doi:10.1074/jbc.M204475200. PMID 12077143. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kim NK, Ahn JY, Song J, et al. (2003). "Expression of the DNA repair enzyme, N-methylpurine-DNA glycosylase (MPG) in astrocytic tumors.". Anticancer Res. 23 (2B): 1417-23. PMID 12820404. 
  • Watanabe S, Ichimura T, Fujita N, et al. (2004). "Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin.". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 12859-64. doi:10.1073/pnas.2131819100. PMID 14555760. 
  • O'Brien PJ, Ellenberger T (2003). "Human alkyladenine DNA glycosylase uses acid-base catalysis for selective excision of damaged purines.". Biochemistry 42 (42): 12418-29. doi:10.1021/bi035177v. PMID 14567703. 
  • O'Brien PJ, Ellenberger T (2004). "Dissecting the broad substrate specificity of human 3-methyladenine-DNA glycosylase.". J. Biol. Chem. 279 (11): 9750-7. doi:10.1074/jbc.M312232200. PMID 14688248. 
  • Likhite VS, Cass EI, Anderson SD, et al. (2004). "Interaction of estrogen receptor alpha with 3-methyladenine DNA glycosylase modulates transcription and DNA repair.". J. Biol. Chem. 279 (16): 16875-82. doi:10.1074/jbc.M313155200. PMID 14761960. 
  • Hitchcock TM, Dong L, Connor EE, et al. (2004). "Oxanine DNA glycosylase activity from Mammalian alkyladenine glycosylase.". J. Biol. Chem. 279 (37): 38177-83. doi:10.1074/jbc.M405882200. PMID 15247209. 
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