Mostafa Ronaghi

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Mostafa Ronaghi is a molecular biologist, specializing in DNA sequencing methodology . He earned his Ph.D. from the Royal Institute of Technology in Sweden. He is currently a principal investigator and Senior Research Associate at the Stanford Genome Technology Center at Stanford University, focusing on developing analytical techniques for molecular diagnostics.

He is principal investigator for several grants including grants from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health ^[1] for the development of array-based Pyrosequencing.

He is an inventor of Pyrosequencing technology and co-founded Pyrosequencing AB in 1997 (renamed to Biotage in 2003), and co-invented Molecular Inversion Probe assay and co-founded ParAllele BioScience to develop this multiplexed technology for genetic testing. ParAllele was acquired by Affymetrix in May 2005. In 2005, he co-founded NextBio, a search engine for life science data. He also serves on the board of directors of Microchip Biotechnologies and Aurora Biofuels.

[edit] Publications

Among his approximately 50 peer-reviewed journal articles are the publications describing Pyrosequencing and Molecular Inversion Probe assays and other techniques:

Absalan F, Ronaghi M. "Molecular inversion probe assay." Methods in Molecular Biology 2007;396:315-30. PMID 18025701
Hardenbol P, Banér J, Jain M, Nilsson M, Namsaraev EA, Karlin-Neumann GA, Fakhrai-Rad H, Ronaghi M, Willis TD, Landegren U, Davis RW. "Multiplexed genotyping with sequence-tagged molecular inversion probes." Nature Biotechnology 2003 Jun;21(6):673-8. Epub 2003 May 5. PMID 12730666
"Prediction of protein orientation upon immobilization on biological and nonbiological surfaces." Proceedings of the National Academy of Sciences 2006 Oct 3;103(40):14773-8. Epub 2006 Sep 25. PMID 17001006
Ronaghi M. "Pyrosequencing sheds light on DNA sequencing." Genome Research 2001 Jan;11(1):3-11. PMID 11156611.
Ronaghi M, Uhlén M, Nyrén P. "A sequencing method based on real-time pyrophosphate." Science 1998 Jul 17;281(5375):363, 365. PMID 9705713.
Ronaghi M, Karamohamed S, Pettersson B, Uhlén M, Nyrén P. "Real-time DNA sequencing using detection of pyrophosphate release." Analytical Biochemistry 1996 Nov 1;242(1):84-9. PMID 8923969.