Talk:Morphinan

From Wikipedia, the free encyclopedia

You have missed out the ether bridge between carbon atoms 4 and 5 - this is neccesary for opioid like actions. I refuse to beleive that methylamphetamine acts in the same way or has similar structures to opioids. Opioids act at defined receptors - mu delta and kappa, producing a cascade of chemical actions in the cell - methamphetamine acts to block the dopamine re-uptake protein at the synapse - thus concentrating dopamine (and to some extent nor-adrenaline) in the synapse - in addition, it encourages the sysnthesis of more dopamine in the pre-synaptic nerve end, but dexamphetamine is better at this than methaphetamine

No, the 4,5-epoxy bridge is not necessary for opioid activity -- see levorphanol, for example.--84.163.107.162 01:59, 14 September 2007 (UTC)

Um, I think Codeinone and Morphinone should be removed from the list of morphinans since they have an intact E ring and thus aren't morphinans. Aj1976 08:21, 6 November 2007 (UTC)