- Alan Morse, guitarist
- A. Reynolds Morse & Eleanor R. Morse, a husband and wife team of American industrialists and philanthropists
- Anthony P. Morse, mathematician and co–author of the Morse–Kelley set theory
- Sir Arthur Morse (1892-1967), British banker
- Arthur D. Morse, historian
- Barry Morse (born 1918), British-Canadian actor
- Brent Morse, businessman
- Carlton E. Morse (1901-1993), American radio producer
- Charles Copeland Morse (born 1842), American businessman
- Charles E. Morse (1841-1920), American soldier
- Christopher Morse, American theologian
- Chuck Morse, American journalist
- Chuck W. Morse (born 1969), American anarchist
- David Morse (born 1953), American actor
- David Morse, Canadian politician
- David A. Morse (1907-1990), American bureaucrat
- Edward S. Morse (1838-1925), American zoologist and anthropologist
- Eleanor Morse, American industrialist and philanthropist
- Elijah A. Morse (1841-1898), American politician
- Ella Mae Morse (1924-1999), American singer
- Elmer A. Morse (1870-1945), American politician
- Emerante Morse, Haitian singer
- Ephraim Morse (1823-1906), American settler of San Diego
- Eric Morse, pen name for author William Pattison
- Erik Morse, journalist and rock writer
- F. Bradford Morse (1921-1994), American politician
- Frank Morse (California attorney), American lawyer and businessman
- Freeman H. Morse (1807-1891), American politician
- Hayward Morse (born 1947), British actor
- Helen Morse (born 1948), Australian actress
- Saint Henry Morse (1595-1645), English priest
- Isaac Edward Morse (1809-1866), American politician
- Jedidiah Morse (1761-1826), American clergyman and geographer, father of Samuel Morse
- Jennifer Morse, journalist
- Sir Jeremy Morse, British educator
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- John Morse, British political candidate
- John Morse (born 1954), American politician
- John Paul Morse (born 1958), American PGA Tour professional golfer
- Joshua Morse, American professor
- Josiah Mitchell Morse American writer
- Ken Morse (born 1949), British cameraman
- Kenneth Morse, American businessman
- Laila Morse (born 1945), British actress
- Lee Morse (1897-1954), American singer
- Leopold Morse (1831-1892), American politician
- Luis C. Morse (born 1940), American politician
- Marston Morse (1892-1977), American mathematician
- Mike Morse (born 1982), American baseball player
- Neal Morse (born 1960), American musician
- Nicholas Morse (died 1772), British president of Madras
- Oliver A. Morse (1815-1870), American politician
- Philip M. Morse (1903-1985), American physicist
- Ralph Morse (born 1917), American photographer
- Ralph Morse (born 1955), English actor, singer, writer and historian
- Rebecca Morse, Australian journalist
- Richard A. Morse (born 1957), Haitian-American musician
- Richard M. Morse (1922-2001), American Latin-American scholar
- Robert Morse (born 1931), American actor
- Roger Morse (1927-2000), American biologist
- Samuel Morse (1791-1872), American inventor and painter; invented the Morse code system
- Scott Morse, American animator
- Sidney Edwards Morse (1794-1871), American inventor
- Stan Morse, American actor
- Stephen Morse (born 1945), American poet
- Stephen Morse, engineer
- Steve Morse (born 1954), American guitarist, member of the group Deep Purple
- Theodora Morse (1883-1953), American lyricist
- Theodore F. Morse (1873-1924), American composer
- Toby Morse, American singer
- Todd Morse, American guitarist
- Wayne Morse (1900-1974), American politician
- Wesley Morse (1897-1963), American cartoonist
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