MORC3

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MORC family CW-type zinc finger 3
Identifiers
Symbol(s) MORC3; NXP2; ZCW5; ZCWCC3
External IDs OMIM: 610078 MGI: 2136841 HomoloGene: 32257
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23515 338467
Ensembl ENSG00000159256 ENSMUSG00000039456
Uniprot Q14149 n/a
Refseq NM_015358 (mRNA)
NP_056173 (protein)		 XM_001004605 (mRNA)
XP_001004605 (protein)
Location Chr 21: 36.61 - 36.67 Mb Chr 16: 93.72 - 93.76 Mb
Pubmed search [1] [2]

MORC family CW-type zinc finger 3, also known as MORC3, is a human gene.[1]

This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled-coil domain.[1]

[edit] References

  1. ^ a b Entrez Gene: MORC3 MORC family CW-type zinc finger 3.

[edit] Further reading

  • Perry J, Zhao Y (2004). "The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants.". Trends Biochem. Sci. 28 (11): 576-80. PMID 14607086. 
  • Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167-74, 199-210. PMID 8590280. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311-9. doi:10.1038/35012518. PMID 10830953. 
  • Kimura Y, Sakai F, Nakano O, et al. (2002). "The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains.". J. Biol. Chem. 277 (23): 20611-7. doi:10.1074/jbc.M201440200. PMID 11927593. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Rosendorff A, Sakakibara S, Lu S, et al. (2006). "NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5308-13. doi:10.1073/pnas.0601066103. PMID 16567619. 
  • Takahashi K, Yoshida N, Murakami N, et al. (2007). "Dynamic regulation of p53 subnuclear localization and senescence by MORC3.". Mol. Biol. Cell 18 (5): 1701-9. doi:10.1091/mbc.E06-08-0747. PMID 17332504. 
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