Molecular imprinted polymer
From Wikipedia, the free encyclopedia
A molecular imprinted polymer (MIP) is a polymer that was formed in the presence of a molecule that is extracted afterwards, thus leaving complementary cavities behind. These polymers show a certain chemical affinity for the original molecule and can be used to fabricate sensors, catalysis or for separation methods. The functional mechanism is similar to antibodies or enzymes.
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[edit] Properties
The target molecule should have one or more functional groups and should not be polymerisable or retard the polymerisation process.
[edit] History
The first imprinted material were sodium silicate based and the first experimental use of these material for separation of dyes in 1949.
[edit] Imprinting process
- Mixing of
- Target molecule
- Polymer
- Formation of prepolymerisation complex: (non-)covalent bonds: Hydrogen bonds, Van der Waals bonds, ionic bonds, hydrophobic interactions, pi-pi interactions
- Polymerisation
- Crosslinker (e.g. EGDM, p-divinylbenzene)
- Initiator (e.g. AIBN)
- Porogen (apolar, non-protogenic solvent)
- Chemical extraction of target molecule and hydrolysis of covalent bonds
[edit] See also
[edit] References
- G. Vlatakis, L. I. Andersson, R. Müller, K. Mosbach (1993). "Drug assay using antibody mimics made by molecular imprinting". Nature 361: 645–647. doi:.
- Frank H. Dickey (1949). "The Preparation of Specific Adsorbents". Proceedings of the National Academy of Sciences 35: 227–229. doi:.
- Simon, Ryan; Collins, Melissa E.; Spivak, David A. (2007). "Shape selectivity versus functional group pre-organization in molecularly imprinted polymers.". Analytica Chimica Acta 591(1): 7–16. doi:.
- C. Alexander , H. S. Andersson, L. I. Andersson, R. J. Ansell, N. Kirsch, I. A. Nicholls, J. O’Mahony, M. J. Whitcombe (2006). "Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003". Journal Molecular Recognition 19: 106–180. doi:.
