MOAP1

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Modulator of apoptosis 1
Identifiers
Symbol(s) MOAP1; MAP-1; PNMA4
External IDs OMIM: 609485 MGI: 1915555 HomoloGene: 11154
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 64112 64113
Ensembl ENSG00000165943 ENSMUSG00000041716
Uniprot Q96BY2 Q9ERH6
Refseq NM_022151 (mRNA)
NP_071434 (protein)		 NM_022323 (mRNA)
NP_071718 (protein)
Location Chr 14: 92.72 - 92.72 Mb Chr 12: 103.14 - 103.16 Mb
Pubmed search [1] [2]

Modulator of apoptosis 1, also known as MOAP1, is a human gene.[1]

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.[1]

[edit] References

  1. ^ a b Entrez Gene: MOAP1 modulator of apoptosis 1.

[edit] Further reading

  • Tan KO, Tan KM, Chan SL, et al. (2001). "MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains.". J. Biol. Chem. 276 (4): 2802-7. doi:10.1074/jbc.M008955200. PMID 11060313. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Baksh S, Tommasi S, Fenton S, et al. (2005). "The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.". Mol. Cell 18 (6): 637-50. doi:10.1016/j.molcel.2005.05.010. PMID 15949439. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Vos MD, Dallol A, Eckfeld K, et al. (2006). "The RASSF1A tumor suppressor activates Bax via MOAP-1.". J. Biol. Chem. 281 (8): 4557-63. doi:10.1074/jbc.M512128200. PMID 16344548. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
  • Fu NY, Sukumaran SK, Yu VC (2007). "Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria.". Proc. Natl. Acad. Sci. U.S.A. 104 (24): 10051-6. doi:10.1073/pnas.0700007104. PMID 17535899. 
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