MLCK

From Wikipedia, the free encyclopedia

MLCK protein

Identifiers

MLCK; MGC126319; MGC126320; MLCK2

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_182493 (mRNA)
NP_872299 (protein)

XM_001001107 (mRNA)
XP_001001107 (protein)

Location

Chr 16: 45.3 - 45.34 Mb

Chr 8: 88.21 - 88.26 Mb

Pubmed search

[1]

[2]

MLCK protein, also known as MLCK (Myosin Light Chain Kinase), is a human gene.^[1]

[edit] References

^ Entrez Gene: MLCK MLCK protein.

[edit] Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Clayburgh DR, Rosen S, Witkowski ED, et al. (2005). "A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.". J. Biol. Chem. 279 (53): 55506-13. doi:10.1074/jbc.M408822200. PMID 15507455.
Wang F, Graham WV, Wang Y, et al. (2005). "Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.". Am. J. Pathol. 166 (2): 409-19. PMID 15681825.
Russo JM, Florian P, Shen L, et al. (2005). "Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.". Gastroenterology 128 (4): 987-1001. PMID 15825080.
Shimizu S, Yoshida T, Wakamori M, et al. (2006). "Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.". J. Physiol. (Lond.) 570 (Pt 2): 219-35. doi:10.1113/jphysiol.2005.097998. PMID 16284075.
Kim MT, Kim BJ, Lee JH, et al. (2006). "Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells.". Am. J. Physiol., Cell Physiol. 290 (4): C1031-40. doi:10.1152/ajpcell.00602.2004. PMID 16306123.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Connell LE, Helfman DM (2007). "Myosin light chain kinase plays a role in the regulation of epithelial cell survival.". J. Cell. Sci. 119 (Pt 11): 2269-81. doi:10.1242/jcs.02926. PMID 16723733.
Seguchi O, Takashima S, Yamazaki S, et al. (2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.". J. Clin. Invest. 117 (10): 2812-24. doi:10.1172/JCI30804. PMID 17885681.