MKNK2

From Wikipedia, the free encyclopedia

MAP kinase interacting serine/threonine kinase 2

PDB rendering based on 2ac3.

Available structures: 2ac3, 2ac5, 2hw7

Identifiers

Symbol(s)

MKNK2; GPRK7; MNK2

External IDs

OMIM: 605069 MGI: 894279 HomoloGene: 49674

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein binding • ATP binding • zinc ion binding • transferase activity
Biological Process:	• regulation of translation • protein amino acid phosphorylation • cell surface receptor linked signal transduction • protein kinase cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017572 (mRNA)
NP_060042 (protein)

NM_021462 (mRNA)
NP_067437 (protein)

Location

Chr 19: 1.99 - 2 Mb

Chr 10: 80.07 - 80.08 Mb

Pubmed search

[1]

[2]

MAP kinase interacting serine/threonine kinase 2, also known as MKNK2, is a human gene.^[1]

[edit] References

^ Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2.

[edit] Further reading

Haribabu B, Snyderman R (1993). "Identification of additional members of human G-protein-coupled receptor kinase multigene family.". Proc. Natl. Acad. Sci. U.S.A. 90 (20): 9398–402. PMID 8415712.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.". EMBO J. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. PMID 9155017.
Slentz-Kesler K, Moore JT, Lombard M, et al. (2001). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta.". Genomics 69 (1): 63–71. doi:10.1006/geno.2000.6299. PMID 11013076.
Scheper GC, Morrice NA, Kleijn M, Proud CG (2001). "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.". Mol. Cell. Biol. 21 (3): 743–54. doi:10.1128/MCB.21.3.743-754.2001. PMID 11154262.
Knauf U, Tschopp C, Gram H (2001). "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.". Mol. Cell. Biol. 21 (16): 5500–11. doi:10.1128/MCB.21.16.5500-5511.2001. PMID 11463832.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scheper GC, Parra JL, Wilson M, et al. (2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.". Mol. Cell. Biol. 23 (16): 5692–705. PMID 12897141.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Yoshizuka N, Yoshizuka-Chadani Y, Krishnan V, Zeichner SL (2005). "Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway.". J. Virol. 79 (17): 11366–81. doi:10.1128/JVI.79.17.11366-11381.2005. PMID 16103188.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Jauch R, Jäkel S, Netter C, et al. (2006). "Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.". Structure 13 (10): 1559–68. doi:10.1016/j.str.2005.07.013. PMID 16216586.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Wang P, Wang X, Wang F, et al. (2006). "Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex.". Sci. China, C, Life Sci. 49 (3): 265–73. PMID 16856496.