MKI67IP

From Wikipedia, the free encyclopedia

MKI67 (FHA domain) interacting nucleolar phosphoprotein

PDB rendering based on 2aff.

Available structures: 2aff

Identifiers

Symbol(s)

MKI67IP; NIFK; Nopp34

External IDs

MGI: 1915199 HomoloGene: 49862

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • protein binding
Cellular Component:	• condensed nuclear chromosome • nucleus • nucleoplasm • nucleolus • cytoplasm
Biological Process:	• protein complex assembly • rRNA transcription • rRNA metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_032390 (mRNA)
NP_115766 (protein)

NM_026472 (mRNA)
NP_080748 (protein)

Location

Chr 2: 122.2 - 122.21 Mb

Chr 1: 120.15 - 120.16 Mb

Pubmed search

[1]

[2]

MKI67 (FHA domain) interacting nucleolar phosphoprotein, also known as MKI67IP, is a human gene.^[1]

[edit] References

^ Entrez Gene: MKI67IP MKI67 (FHA domain) interacting nucleolar phosphoprotein.

[edit] Further reading

Takagi M, Sueishi M, Saiwaki T, et al. (2001). "A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis.". J. Biol. Chem. 276 (27): 25386–91. doi:10.1074/jbc.M102227200. PMID 11342549.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Li H, Byeon IJ, Ju Y, Tsai MD (2004). "Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions.". J. Mol. Biol. 335 (1): 371–81. PMID 14659764.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Byeon IJ, Li H, Song H, et al. (2006). "Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67.". Nat. Struct. Mol. Biol. 12 (11): 987–93. doi:10.1038/nsmb1008. PMID 16244663.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.