Mitochondrial myopathy

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Mitochondrial myopathy Classification and external resources
Simplified structure of a typical mitochondrion
ICD-10	G 71.3
MeSH	D017240

Mitochondrial myopathy are a type of myopathy associated with mitochondrial disease.

[edit] Treatment

Although no cure currently exists, there is some hope for a treatment for this whole class of hereditary diseases with the use of an embryotic mitochindrial transplant. ^[1]

[edit] Examples

Examples of Mitochondrial myopathy include:

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like syndrome (MELAS)
- varying degrees of cognitive impairment and dementia
- lactic acidosis
- strokes
- transient ischemic attacks
- hearing loss
- dysmotility
- weight loss

Myoclonic epilepsy and ragged-red fibers (MERRF)
- progressive myoclonic epilepsy
- clumps of diseased mitochondria accumulate in the subsarcolemmal region of the muscle fiber and appear as "ragged-red fibers" when muscle is stained with modified Gomori trichrome stain
- short stature

Kearns-Sayre syndrome (KSS)
- external ophthalmoplegia
- cardiac conduction defects
- sensory-neural hearing loss

Progressive external ophthalmoplegia (PEO)
- progressive ophthalmoparesis is the cardinal feature
- symptomatic overlap with many other mitochondrial myopathies

[edit] References

^ Three-parent embryo formed in lab (web). Scientists believe they have made a potential breakthrough in the treatment of serious disease by creating a human embryo with three separate parents.. BBC News (Tuesday, 5 February 2008, 11:13 GMT). Retrieved on 2008-02-08.

v • d • e Nervous system pathology, primarily PNS (G50-G99, 350-359)

Nerve, nerve root and plexus disorders (neuropathy, radiculopathy, plexopathy)	cranial nerve: V (Trigeminal neuralgia) - VII (Facial nerve paralysis, Bell's palsy, Melkersson-Rosenthal syndrome, Central seven) - XI (Accessory nerve disorder) nerve root and plexus: Brachial plexus lesion - Thoracic outlet syndrome - Phantom limb mononeuropathy: upper limb (Carpal tunnel syndrome, Ulnar nerve entrapment, Radial neuropathy) - Causalgia - lower limb (Meralgia paraesthetica, Tarsal tunnel syndrome, Morton's neuroma) - Mononeuritis multiplex

Polyneuropathies and other disorders of the PNS	hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease, Dejerine Sottas syndrome, Refsum's disease) Guillain-Barré syndrome - Alcoholic polyneuropathy

Diseases of myoneural junction	autoimmune: Myasthenia gravis - Lambert-Eaton myasthenic syndrome

Diseases of muscle (myopathy)/ neuromuscular disease	Muscular dystrophy myotonic (Myotonic dystrophy, Myotonia congenita, Thomsen disease, Neuromyotonia, Paramyotonia congenita) congenital myopathy (Centronuclear myopathy, Nemaline myopathy, Central core disease) Mitochondrial myopathy periodic paralysis: Hypokalemic - Hyperkalemic

Dysautonomia/ Autonomic neuropathy	Hereditary sensory and autonomic neuropathy (Familial dysautonomia) - Horner's syndrome - Multiple system atrophy (Shy-Drager syndrome, Olivopontocerebellar atrophy)