Mitochondrial carrier

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Mitochondrial ADP/ATP carrier
Identifiers
Symbol	Mito_carr
Pfam	PF00153
InterPro	IPR001993
PROSITE	PDOC00189
SCOP	1okc
TCDB	2.A.29
OPM family	21
OPM protein	1okc
Available PDB structures: 2bmnA:9-104 2c3eA:112-206 1ymjA:112-206 1okcA:112-206 1ym6A:112-206

A mitochondrial carrier is a protein in the solute carrier family which transfers molecules across the membranes of the mitochondria.

A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome^[1]^[2]^[3]^[4]^[5]^[6].

Such proteins include: ADP, ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others.

Structurally, these proteins can consist of up to three tandem repeats of a domain of approximately 100 residues, each domain containing two transmembrane regions.

Examples include:

citrate - SLC25A1
ornithine - SLC25A2, SLC25A15
phosphate - SLC25A3, SLC25A23, SLC25A24 , SLC25A25
adenine nucleotide - SLC25A4, SLC25A5, SLC25A6, SLC25A31
dicarboxylate - SLC25A10
oxoglutarate - SLC25A11
glutamate - SLC25A22

[edit] Human proteins containing this domain

HDMCP; LOC153328; MCART1; MCART2; MCART6; MTCH1; MTCH2; SCAMC-2; SLC25A1; SLC25A10; SLC25A11; SLC25A12; SLC25A13; SLC25A14; SLC25A16; SLC25A17; SLC25A18; SLC25A19; SLC25A21; SLC25A22; SLC25A23; SLC25A24; SLC25A25; SLC25A26; SLC25A27; SLC25A28; SLC25A29; SLC25A3; SLC25A30; SLC25A31; SLC25A32; SLC25A33; SLC25A34; SLC25A35; SLC25A36; SLC25A37; SLC25A38; SLC25A39; SLC25A4; SLC25A40; SLC25A41; SLC25A42; SLC25A43; SLC25A44; SLC25A45; SLC25A46; SLC25A5; SLC25A6; UCP1; UCP2; UCP3;

[edit] References

^ Klingenberg M (1990). "Mechanism and evolution of the uncoupling protein of brown adipose tissue". Trends Biochem. Sci. 15 (3): 108–112. doi:10.1016/0968-0004(90)90194-G. PMID 2158156.
^ Walker JE (1992). "The mitochondrial transporter family". Curr. Opin. Struct. Biol. 2: 519–526. doi:10.1016/0959-440X(92)90081-H.
^ Kuan J, Saier Jr MH (1993). "Expansion of the mitochondrial carrier family". Res. Microbiol. 144 (8): 671–672. doi:10.1016/0923-2508(93)90073-B. PMID 8140286.
^ Lawson JE, Nelson DR, Klingenberg M, Douglas MG (1993). "Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential". J. Mol. Biol. 230 (4): 1159–1170. doi:10.1006/jmbi.1993.1233. PMID 8487299.
^ Palmieri F (1994). "Mitochondrial carrier proteins". FEBS Lett. 346 (1): 48–54. doi:10.1016/0014-5793(94)00329-7. PMID 8206158.
^ Jank B, Schweyen RJ, Link TA, Habermann B (1993). "PMP47, a peroxisomal homologue of mitochondrial solute carrier proteins". Trends Biochem. Sci. 18 (11): 427–428. PMID 8291088.