Missouri Route 181

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Route 181
Maintained by MoDOT
Length:	55 mi (89 km)
North end:	Cabool
South end:	Gainesville
Major cities:	Cabool Dora Sycamore Zanoni Gainesville
Missouri Highways < Route 180 Route 185 > Supplemental

Route 181 is a highway in southern Missouri. Its northern terminus is at Business U.S. Route 60 in Cabool; its southern terminus is at U.S. Route 160 in Gainesville.

The road intersects with Route 14 near the twin bridges. It runs concurrently with Route 14 westward for about 1 mile, then heads back south toward Dora. About three miles south of Dora, near Highway CC, Route 181 heads west again toward the Hodgson and Zanoni mills, while Highway H continues southward toward US 160.