MIS12

From Wikipedia, the free encyclopedia

MIS12, MIND kinetochore complex component, homolog (yeast)

Identifiers

MIS12; KNTC2AP; 2510025F08Rik; MGC2488; MTW1; hMis12

External IDs

OMIM: 609178 MGI: 1914389 HomoloGene: 11429

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• chromosome, pericentric region • condensed nuclear chromosome kinetochore • nucleus
Biological Process:	• cell cycle • chromosome segregation • mitosis • cell division • kinetochore assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_024039 (mRNA)
NP_076944 (protein)

NM_025993 (mRNA)
NP_080269 (protein)

Location

Chr 17: 5.33 - 5.33 Mb

Chr 11: 70.84 - 70.84 Mb

Pubmed search

[1]

[2]

MIS12, MIND kinetochore complex component, homolog (yeast), also known as MIS12, is a human gene.^[1]

[edit] References

^ Entrez Gene: MIS12 MIS12, MIND kinetochore complex component, homolog (yeast).

[edit] Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Goshima G, Kiyomitsu T, Yoda K, Yanagida M (2003). "Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway.". J. Cell Biol. 160 (1): 25-39. doi:10.1083/jcb.200210005. PMID 12515822.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Cheeseman IM, Niessen S, Anderson S, et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.". Genes Dev. 18 (18): 2255-68. doi:10.1101/gad.1234104. PMID 15371340.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Obuse C, Iwasaki O, Kiyomitsu T, et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.". Nat. Cell Biol. 6 (11): 1135-41. doi:10.1038/ncb1187. PMID 15502821.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Kline SL, Cheeseman IM, Hori T, et al. (2006). "The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation.". J. Cell Biol. 173 (1): 9-17. doi:10.1083/jcb.200509158. PMID 16585270.