Mirfentanil
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| Mirfentanil | |
|---|---|
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| IUPAC name | N-[1-(2-phenylethyl)piperidin-4-yl]-
N-pyrazin-2-ylfuran-2-carboxamide |
| Other names | MS-32, NIH-10647 |
| Identifiers | |
| CAS number | [117523-47-4] |
| PubChem | |
| SMILES | C1CN(CCC1N(C2=NC=CN=C2)C(=O)
C3=CC=CO3)CCC4=CC=CC=C4 |
| Properties | |
| Molecular formula | C22H24N4O2 |
| Molar mass | 376.45 g mol-1 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Mirfentanil is a fentanyl derivative with strong selectivity for the μ opioid receptor. At lower doses, it antagonizes the analgesic effects of alfentanil and substitutes for naloxone in morphine-treated monkeys; however, it also reverses naloxone-precipitated withdrawal in pigeons trained to discriminate morphine from naloxone.[1]
At high doses, it exhibits analgesic activity which is not fully reversed by opioid antagonists, suggesting that the drug has both opioid and non-opioid mechanisms of action.[1][2]
[edit] References
- ^ a b France CP, Winger G, Medzihradsky F, Seggel MR, Rice KC, Woods JH. "Mirfentanil: pharmacological profile of a novel fentanyl derivative with opioid and nonopioid effects." Journal of Pharmacology and Experimental Therapeutics. 1991 Aug;258(2):502-10. PMID 1650830
- ^ Carr DJ, Brockunier LL, Scott M, Bagley JR, France CP. "Mirfentanil antagonizes morphine-induced suppression of splenic NK activity in mice." Immunopharmacology. 1996 Aug;34(1):9-16. PMID 8880221
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