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| mir-92 microRNA precursor family |
 |
| Type: |
Gene; miRNA; |
| 2° structure: |
Predicted; PFOLD; |
| Seed alignment: |
Moxon SJ |
| Avg length: |
79.2 nucleotides |
| Avg identity: |
62% |
|
The miR-92 microRNA precursor family are small non-coding RNA genes that regulate gene expression by antisense binding. This family includes the related mir-92-1 and mir-92-2 sequences. Human miR-92 has two predicted hairpin precursor sequences: mir-92-1 on chromosome 13 and mir-92-2 on chromosome X [1]. miR-92 has also been cloned from mouse embryonic stem cells [2]. The mature sequence is excised from the 3' arm of the hairpin.
miR-92b has been characterised as a cancer associated microRNA [3]
[edit] References
- ^ Mourelatos Z, Dostie J, Paushkin S, et al (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMID 11914277.
- ^ Houbaviy HB, Murray MF, Sharp PA (2003). "Embryonic stem cell-specific MicroRNAs". Dev. Cell 5 (2): 351–8. PMID 12919684.
- ^ Lu J, Getz G, Miska EA, et al (2005). "MicroRNA expression profiles classify human cancers". Nature 435 (7043): 834–8. doi:10.1038/nature03702. PMID 15944708.
[edit] External links
