Mir-8/mir-141/mir-200 microRNA precursor family

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mir-8/mir-141/mir-200 microRNA precursor family

Type:	Gene; miRNA;
2° structure:	Predicted; PFOLD
Seed alignment:	Griffiths-Jones SR
Avg length:	77.2 nucleotides
Avg identity:	64%

The miR-8 microRNA precursor (homologous to miR-141, miR-200), is a short non-coding RNA gene involved in gene regulation. miR-8 from Drosophila ^[1] (MI0000128) and human and mouse mir-141 (MI0000166, MI0000457), mir-429 (MI0001642) and mir-200 (MI0000243, MI0000342) ^[2] are expressed from the 3' arm of related precursor hairpins (represented here). Members of this precursor family have now been predicted or experimentally confirmed in a wide range of species (MIPF0000019). The bounds of the precursors are predicted based on conservation and base pairing and are not generally known.

[edit] Targets of miR-8

The atrophin gene has been shown to be a target of drosophila miR-8.^[3] It has also been suggested that this target is also conserved in mammalian miR-8.

The human miR-200c is likely to target the zinc finger transcription factor transcription factor 8 (TCF8) gene.^[4]

[edit] References

^ Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs". Science 294 (5543): 853–8. doi:10.1126/science.1064921. PMID 11679670.
^ Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T (2003). "New microRNAs from mouse and human". RNA 9 (2): 175–9. PMID 12554859.
^ Karres JS, Hilgers V, Carrera I, Treisman J, Cohen SM (2007). "The Conserved microRNA MiR-8 Tunes Atrophin Levels to Prevent Neurodegeneration in Drosophila". Cell 131 (1): 136–45. doi:10.1016/j.cell.2007.09.020. PMID 17923093.
^ Hurteau GJ, Carlson JA, Spivack SD, Brock GJ (2007). "Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin". Cancer Res. 67 (17): 7972–6. doi:10.1158/0008-5472.CAN-07-1058. PMID 17804704.