From Wikipedia, the free encyclopedia
| mir-46/mir-47/mir-281 microRNA precursor family |
 |
| Type: |
Gene; miRNA; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
76.0 nucleotides |
| Avg identity: |
78% |
|
In molecular biology, mir-46 (MI0000017) and mir-47 (MI0000018) are microRNA expressed in C. elegans from related hairpin precursor sequences.[1] The predicted hairpin precursor sequences for Drosophila mir-281 (MI0000366, MI0000370)[2][3] are also related and, hence, belong to this family. The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequences are expressed from the 3' arms of the hairpin precursors.
[edit] References
- ^ Lau, NC; Lim LP, Weinstein EG, Bartel DP (2001). "An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans". Science 294: 858–862. doi:10.1126/science.1065062. PMID 11679671.
- ^ Lai, EC; Tomancak P, Williams RW, Rubin GM (2003). "Computational identification of Drosophila microRNA genes". Genome Biol 4: R42–. doi:10.1186/gb-2003-4-7-r42. PMID 12844358.
- ^ Aravin, AA; Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T (2003). "The small RNA profile during Drosophila melanogaster development". Dev Cell 5: 337–350. doi:10.1016/S1534-5807(03)00228-4. PMID 12919683.
[edit] External links
