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| mir-30 microRNA precursor |
 |
| Type: |
Gene; miRNA; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
70.8 nucleotides |
| Avg identity: |
82% |
|
miR-30 microRNA precursor is a small non-coding RNA that regulates gene expression. Animal microRNAs are transcribed as ~70 nucleotide stem-loop precursor and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from both the 3' (miR-30)[1] and 5' (mir-97-6)[2] arms of the precursor. The products are thought to have regulatory roles through complementarity to mRNA [3].
[edit] References
- ^ Lagos-Quintana, M; Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs". Science 294: 853–858. doi:10.1126/science.1064921. PMID 11679670.
- ^ Mourelatos, Z; Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev 16: 720–728. doi:10.1101/gad.974702. PMID 11914277.
- ^ Ambros V (2001). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–6. PMID 11779458.
[edit] External links
