Mir-29 microRNA precursor

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miR-29 microRNA precursor

Type:	Gene; miRNA;
2° structure:	Predicted; PFOLD
Seed alignment:	INFERNAL
Avg length:	67.9 nucleotides
Avg identity:	80%

miR-29 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression.^[1] This microRNA (miRNA) has been predicted or confirmed in a wide range of species (MIPF0000009). Animal miRNAs are transcribed as an approximately 70 nucleotide precursor and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor RNA. The products are thought to have regulatory roles through complementarity to mRNA.

[edit] Targets of miR-29

It has been shown that miR-29 regulates the level of the Mcl-1 protein.^[2] Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins.

It has been shown that miR-29 regulates the level of Tcl1 protein.^[3] The Tcl1 (T-cell leukemia/lymphoma 1) oncogene found to be disrupted in many T-cell leukemias.

It has been shown that miR-29 directly target both DNMT3A and DNMT-3B which DNA methyltransferase proteins frequently upregulated in lung cancer.^[4]

[edit] References

^ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell 107: 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
^ Mott JL, Kobayashi S, Bronk SF, Gores GJ (2007). "mir-29 regulates Mcl-1 protein expression and apoptosis". doi:10.1038/sj.onc.1210436. PMID 17404574.
^ Pekarsky Y, Santanam U, Cimmino A, et al (2006). "Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181". Cancer Res. 66 (24): 11590–3. doi:10.1158/0008-5472.CAN-06-3613. PMID 17178851.
^ Fabbri M, Garzon R, Cimmino A, et al (2007). "MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B". Proc. Natl. Acad. Sci. U.S.A. 104 (40): 15805–10. doi:10.1073/pnas.0707628104. PMID 17890317.