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| mir-26 microRNA precursor family |
 |
| Type: |
Gene; miRNA; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
73.5 nucleotides |
| Avg identity: |
80% |
|
The miR-26 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression. miR-26 appears to be a vertebrate specific microRNA[1][2] and has now been predicted or experimentally validated in many vertebrate species (MIPF0000043). In this microRNA the mature sequence is excised from the 5' arm of the hairpin. miR-26 has been shown to be expressed in neural tissue.[3] It has also been suggested that miR-26 is involved in response to low oxygen levels.[4]
[edit] References
- ^ Lagos-Quintana, M; Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs". Science 294: 853–858. doi:10.1126/science.1064921. PMID 11679670.
- ^ Lagos-Quintana, M; Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol 12: 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
- ^ Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R, Wulczyn FG (2005). "Regulation of miRNA expression during neural cell specification". Eur. J. Neurosci. 21 (6): 1469–77. doi:10.1111/j.1460-9568.2005.03978.x. PMID 15845075.
- ^ Kulshreshtha R, Ferracin M, Wojcik SE, et al (2007). "A microRNA signature of hypoxia". Mol. Cell. Biol. 27 (5): 1859–67. doi:10.1128/MCB.01395-06. PMID 17194750.
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