Mir-17 microRNA precursor family

From Wikipedia, the free encyclopedia

mir-17 microRNA precursor family

Type:	Gene; miRNA;
2° structure:	Predicted; PFOLD
Seed alignment:	Griffiths-Jones SR
Avg length:	82.1 nucleotides
Avg identity:	69%

The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression. The microRNA precursor miR-17 family, includes miR-20, miR-91, and miR-103. miRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The products are thought to have regulatory roles through complementarity to the 3' UTR of mRNA.

[edit] References

[1] Lagos-Quintana, M; Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs". Science 294: 853–858. doi:10.1126/science.1064921. PMID 11679670.
[2] Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell 107: 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.