From Wikipedia, the free encyclopedia
| mir-16 microRNA precursor family |
 |
| Type: |
Gene; miRNA; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
80.4 nucleotides |
| Avg identity: |
76% |
|
The miR-16 microRNA precursor family is a group of related small non-coding RNA genes that regulate gene expression. miR-16, miR-15, mir-195 and miR-457 are related microRNA precursor sequences (MIPF000006). This microRNA family appears to be vertebrate specific and members of this family have been predicted or experimentally validated in a wide range of vertebrate species (MIPF0000006). miR-16 and miR-15a are clustered within 0.5 kilobases at 13q14 in human, a chromosomal region shown to be deleted or down-regulated in more than half of B cell chronic lymphocytic leukaemias (CLL).[1]
[edit] References
- ^ Calin, GA; Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM (2002). "Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia". Proc Natl Acad Sci U S A 99: 15524–15529. doi:10.1073/pnas.242606799. PMID 12434020.
[edit] External links
