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| mir-15 microRNA precursor family |
 |
| Type: |
Gene; miRNA; |
| 2° structure: |
Predicted; RNAFOLD |
| Seed alignment: |
Moxon SJ |
| Avg length: |
85.4 nucleotides |
| Avg identity: |
80% |
|
The miR-15 microRNA precursor family are small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences. In humans miR-15a and miR-16 are clustered within 0.5 kilobases at 13q14.[1] This region has been shown to be deleted in more than half of B cell chronic lymphocytic leukaemias (CLL). Both miR-15a and miR-16 are deleted or down-regulated in more than two thirds of CLL cases.[2] The mature sequence is excised from the 5' arm of the hairpin.
[edit] References
- ^ Lagos-Quintana, M; Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs". Science 294: 853–858. doi:10.1126/science.1064921. PMID 11679670.
- ^ Calin, GA; Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM (2002). "Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia". Proc Natl Acad Sci U S A 99: 15524–15529. doi:10.1073/pnas.242606799. PMID 12434020.
[edit] External links
