Mir-148/mir-152 microRNA precursor family

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miR-148/miR-152 microRNA precursor family

Type:	Gene; miRNA;
2° structure:	Predicted; PFOLD
Seed alignment:	Griffiths-Jones SR
Avg length:	86.2 nucleotides
Avg identity:	71%

In molecular biology, miR-148 is a microRNA whose expression has been demonstrated in human (MI0000253), mouse (MI0000550), rat (MI0000616) and zebrafish (MI0002015).^[1]^[2]^[3] miR-148 has also been predicted in chicken (MI0001189).

These predicted hairpin precursor sequence are related to those of miR-152, which has been expressed in mouse (MI0000174) and is predicted in human (MI0000462).^[1]

The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 3' arm of the hairpin.

[edit] Targets of miR-148

MicroRNAs act by lowering the expression of genes by binding to target sites in the 3' UTR of the mRNAs. However recently it was shown by Duursma and colleagues that miR-148 down regulates Dnmt3b by binding to a region in the protein coding region.^[4]

[edit] References

^ ^a ^b Lagos-Quintana, M; Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol 12: 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
^ Kim, J; Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G (2004). "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons". Proc Natl Acad Sci U S A 101: 360–365. doi:10.1073/pnas.2333854100. PMID 14691248.
^ Chen, PY; Manninga H, Slanchev K, Chien M, Russo JJ, Ju J, Sheridan R, John B, Marks DS, Gaidatzis D, Sander C, Zavolan M, Tuschl T (2005). "The developmental miRNA profiles of zebrafish as determined by small RNA cloning". Genes Dev. 19: 1288–1293. doi:10.1101/gad.1310605. PMID 15937218.
^ Duursma AM, Kedde M, Schrier M, le Sage C, Agami R (May 2008). "miR-148 targets human DNMT3b protein coding region". RNA 14 (5): 872–7. doi:10.1261/rna.972008. PMID 18367714.