From Wikipedia, the free encyclopedia
| mir-135 microRNA precursor family |
 |
| Type: |
Gene; miRNA; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
90.2 nucleotides |
| Avg identity: |
75% |
|
The miR-135 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression. It has been shown to be expressed in human, mouse and rat.[1][2] miR-135 has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000028). Precursor microRNAs are ~70 nucleotides in length and are processed by the Dicer enzyme to produce the shorter 21-24 nucleotide mature sequence. In this case the mature sequence is excised from the 5' arm of the hairpin.
[edit] References
- ^ Lagos-Quintana, M; Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol 12: 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
- ^ Kim, J; Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G (2004). "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons". Proc Natl Acad Sci U S A 101: 360–365. doi:10.1073/pnas.2333854100. PMID 14691248.
[edit] External links
