From Wikipedia, the free encyclopedia
| mir-130 microRNA precursor family |
 |
| Type: |
Gene; miRNA; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
82.5 nucleotides |
| Avg identity: |
72% |
|
In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408),[1] and in human (MI0000448, MI0000748).[2] miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma.[3]
[edit] References
- ^ Lagos-Quintana, M; Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol 12: 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
- ^ Houbaviy, HB; Murray MF, Sharp PA (2003). "Embryonic stem cell-specific MicroRNAs". Dev Cell 5: 351–358. doi:10.1016/S1534-5807(03)00227-2. PMID 12919684.
- ^ Kutay H, Bai S, Datta J, et al (2006). "Downregulation of miR-122 in the rodent and human hepatocellular carcinomas". J. Cell. Biochem. 99 (3): 671–8. doi:10.1002/jcb.20982. PMID 16924677.
[edit] External links
