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| mir-124 microRNA precursor family |
 |
| Type: |
Gene; miRNA; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
Griffiths-Jones SR |
| Avg length: |
80.6 nucleotides |
| Avg identity: |
85% |
|
The miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies (MI0000373),[1] nematode worms (MI0000302),[2] mouse (MI0000150) and human (MI0000443).[3] The mature ~21 nucleotide microRNAs are processed from hairpin precursor sequences by the Dicer enzyme, and in this case originates from the 3' arm. miR-124 has been found to be the most abundant microRNA expressed in neuronal cells. Experiments to alter expression of miR-124 in neural cells did not appear to affect differentiation.[4]
[edit] Targets of miR-124
- Visvanathan et al. showed that miR-124 targets the mRNA of the anti-neural function protein SCP1 (small C-terminal domain phosphatase 1).[5]
[edit] References
- ^ Lai, EC; Tomancak P, Williams RW, Rubin GM (2003). "Computational identification of Drosophila microRNA genes". Genome Biol 4: R42–. doi:10.1186/gb-2003-4-7-r42. PMID 12844358.
- ^ Lim, LP; Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, Burge CB, Bartel DP (2003). "The microRNAs of Caenorhabditis elegans". Genes Dev 17: 991–1008. doi:10.1101/gad.1074403. PMID 12672692.
- ^ Lagos-Quintana, M; Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol 12: 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
- ^ Cao X, Pfaff SL, Gage FH (2007). "A functional study of miR-124 in the developing neural tube". Genes Dev. 21 (5): 531–6. doi:10.1101/gad.1519207. PMID 17344415.
- ^ Visvanathan J, Lee S, Lee B, Lee JW, Lee SK (2007). "The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development". Genes Dev. 21 (7): 744–9. doi:10.1101/gad.1519107. PMID 17403776.
[edit] External links
