Mir-103/107 microRNA precursor

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mir-103/107 microRNA precursor

Type:	Gene; miRNA;
2° structure:	Predicted; PFOLD
Seed alignment:	Griffiths-Jones SR
Avg length:	78.0 nucleotides
Avg identity:	85%

The miR-103 microRNA precursor (homologous to miR-107), is a short non-coding RNA gene involved in gene regulation. miR-103 and miR-107 have now been predicted or experimentally confirmed in human ^[1] (MIPF0000024). microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA ^[2].

[edit] References

^ Mourelatos Z, Dostie J, Paushkin S, et al (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMID 11914277.
^ Ambros V (2001). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–6. PMID 11779458.