MINPP1

From Wikipedia, the free encyclopedia

Multiple inositol polyphosphate histidine phosphatase, 1

Identifiers

MINPP1; DKFZp564L2016; HIPER1; MINPP2; MIPP

External IDs

OMIM: 605391 MGI: 1336159 HomoloGene: 37980

Gene ontology
Molecular Function:	• acid phosphatase activity • multiple inositol-polyphosphate phosphatase activity • phosphohistidine phosphatase activity • hydrolase activity
Cellular Component:	• endoplasmic reticulum
Biological Process:	• polyphosphate metabolic process • bone mineralization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004897 (mRNA)
NP_004888 (protein)

NM_010799 (mRNA)
NP_034929 (protein)

Location

Chr 10: 89.25 - 89.3 Mb

Chr 19: 32.55 - 32.58 Mb

Pubmed search

[1]

[2]

Multiple inositol polyphosphate histidine phosphatase, 1, also known as MINPP1, is a human gene.^[1]

MINPP1 hydrolyzes the abundant metabolites inositol pentakisphosphate and inositol hexakisphosphate and, like PTEN (MIM 601728), has the ability to remove 3-phosphate from inositol phosphate substrates.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: MINPP1 multiple inositol polyphosphate histidine phosphatase, 1.

[edit] Further reading

Romano PR, Wang J, O'Keefe RJ, et al. (1998). "HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation.". J. Cell. Sci. 111 ( Pt 6): 803-13. PMID 9472008.
Caffrey JJ, Hidaka K, Matsuda M, et al. (1999). "The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification.". FEBS Lett. 442 (1): 99-104. PMID 9923613.
Chi H, Tiller GE, Dasouki MJ, et al. (1999). "Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19.". Genomics 56 (3): 324-36. doi:10.1006/geno.1998.5736. PMID 10087200.
Chi H, Yang X, Kingsley PD, et al. (2000). "Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo.". Mol. Cell. Biol. 20 (17): 6496-507. PMID 10938126.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Gimm O, Chi H, Dahia PL, et al. (2001). "Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas.". J. Clin. Endocrinol. Metab. 86 (4): 1801-5. PMID 11297621.
VanHouten JN, Asch HL, Asch BB (2001). "Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas.". Oncogene 20 (38): 5366-72. doi:10.1038/sj.onc.1204701. PMID 11536049.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.