MINK1

From Wikipedia, the free encyclopedia

Misshapen-like kinase 1 (zebrafish)

Identifiers

MINK1; B55; MAP4K6; MGC21111; MINK; YSK2; ZC3; hMINK; hMINKbeta

External IDs

OMIM: 609426 MGI: 1355329 HomoloGene: 56762

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • small GTPase regulator activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • response to stress • protein kinase cascade • JNK cascade • multicellular organismal development • negative thymic T cell selection

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001024937 (mRNA)
NP_001020108 (protein)

NM_001045959 (mRNA)
NP_001039424 (protein)

Location

Chr 17: 4.73 - 4.74 Mb

Chr 11: 70.38 - 70.43 Mb

Pubmed search

[1]

[2]

Misshapen-like kinase 1 (zebrafish), also known as MINK1, is a human gene.^[1]

This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: MINK1 misshapen-like kinase 1 (zebrafish).

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Dan I, Watanabe NM, Kobayashi T, et al. (2000). "Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development.". FEBS Lett. 469 (1): 19-23. PMID 10708748.
Dan I, Watanabe NM, Kajikawa E, et al. (2002). "Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution.". Nucleic Acids Res. 30 (13): 2906-10. PMID 12087176.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205-20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Campdelacreu J, Ezquerra M, Muñoz E, et al. (2003). "Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy.". Neurosci. Lett. 340 (2): 158-60. PMID 12668260.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Hu Y, Leo C, Yu S, et al. (2005). "Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta.". J. Biol. Chem. 279 (52): 54387-97. doi:10.1074/jbc.M404497200. PMID 15469942.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.