Microstimulation

From Wikipedia, the free encyclopedia

This article may require cleanup to meet Wikipedia's quality standards. Please improve this article if you can. (February 2008)

This article does not cite any references or sources. (February 2008) Please help improve this article by adding citations to reliable sources. Unverifiable material may be challenged and removed.

Please help improve this article or section by expanding it. Further information might be found on the talk page or at requests for expansion. (February 2008)

Microstimulation is a technique that stimulates a group of nerve cells by zapping them with a small electrical current.

[edit] Applications

Microstimulation is used in neuroanatomical research to identify the functional significance of a group of neurons. For example, Vidal-Gonzalez et al. (2006) ^[1] applied microstimulation to the rat prelimbic and infralimbic subregions of the medial prefrontal cortex while testing the subjects in a fear-inducing low-footshock condition for various behavioral indicators of fear (such as freezing). This test allowed them to compare the relative fear behavior of rats under microstimulation in either subregion to normal rats in the same condition. The researchers concluded that the prelimbic subregion excites fear behavior while the infralimbic subregion inhibits fear behavior. In this instance, the correlation between stimulation and behavior helped identify the function of these two subregions in the process of fear.