Michelin tire baby syndrome

From Wikipedia, the free encyclopedia

Michelin Tire Baby Syndrome, also known as congenital diffuse lipomatosis, is characterized by multiple, symmetric, circumferential skin creases, or bands, on the forearms, lower legs, and often the neck that are present at birth. The creases disappear later in life. They are reminiscent of these of the mascot of the tire manufacturer, Michelin, hence the name of the syndrome. Associated abnormalities vary and may include facial dysmorphism, upslanting palpebral fissures, hypertelorism, cleft palate, genital anomalies, mild developmental delay, ureterocele, smooth muscle hamartoma, nevus lipomatosus, Laron syndrome (dwarfism with high growth hormone and low somatomedin activity), and other defects. It was originally described by Ross in 1969. Twenty cases of this hamartomatous disorder have been reported.

[edit] References

Ross CM: Generalized folded skin with an underlying lipomatous nevus: "The Michelin tire baby." Arch Dermatol 1969;100:320
Schnur RE, Herzberg AJ, Spinner N, et al: Variability in the Michelin tire syndrome: A child with multiple anomalies, smooth muscle hamartoma, and familial paracentric inversion of chromosome 7q. J Am Acad Dermatol 1993;28:364
Schnur RE, Zackai EH: Circumferential ringed creases ("Michelin tire babies") with specific histologic findings and/or karyotype abnormalities: Clues to molecular pathogenesis? (Letter) Am J Med Genet 1997;69:221
Pivnick EK, Wilroy RS, Martens PR, et al: Hypertrichosis, pigmentary retinopathy, and facial anomalies: A new syndrome? Am J Med Genet 1996;62:386
Oku T, Iwasaki K, Fujita H: Folded skin with an underlying cutaneous smooth muscle hamartoma. Brit J Dermatol 1993;129:606