MICB

From Wikipedia, the free encyclopedia

MHC class I polypeptide-related sequence B

PDB rendering based on 1je6.

Available structures: 1je6

Identifiers

Symbol(s)

MICB; PERB11.2

External IDs

OMIM: 602436 MGI: 2179988 HomoloGene: 88497

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• membrane • integral to membrane • MHC class I protein complex
Biological Process:	• response to stress • cellular defense response • cell recognition • antigen processing and presentation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005931 (mRNA)
NP_005922 (protein)

XM_985454 (mRNA)
XP_990548 (protein)

Location

Chr c6_QBL: 31.6 - 31.61 Mb

Chr 7: 17.4 - 17.42 Mb

Pubmed search

[1]

[2]

MHC class I polypeptide-related sequence B, also known as MICB, is a human gene.

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides.^[1]

[edit] References

^ Entrez Gene: MICB MHC class I polypeptide-related sequence B.

[edit] Further reading

Braud VM, Allan DS, McMichael AJ (1999). "Functions of nonclassical MHC and non-MHC-encoded class I molecules.". Curr. Opin. Immunol. 11 (1): 100–8. PMID 10047540.
Borrego F, Kabat J, Kim DK, et al. (2002). "Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells.". Mol. Immunol. 38 (9): 637–60. PMID 11858820.
Leelayuwat C, Townend DC, Degli-Esposti MA, et al. (1994). "A new polymorphic and multicopy MHC gene family related to nonmammalian class I.". Immunogenetics 40 (5): 339–51. PMID 7927538.
Bahram S, Bresnahan M, Geraghty DE, Spies T (1994). "A second lineage of mammalian major histocompatibility complex class I genes.". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6259–63. PMID 8022771.
Bahram S, Spies T (1996). "Nucleotide sequence of a human MHC class I MICB cDNA.". Immunogenetics 43 (4): 230–3. PMID 8575823.
Nalabolu SR, Shukla H, Nallur G, et al. (1997). "Genes in a 220-kb region spanning the TNF cluster in human MHC.". Genomics 31 (2): 215–22. doi:10.1006/geno.1996.0034. PMID 8824804.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Groh V, Bahram S, Bauer S, et al. (1996). "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12445–50. PMID 8901601.
Bahram S, Shiina T, Oka A, et al. (1997). "Genomic structure of the human MHC class I MICB gene.". Immunogenetics 45 (2): 161–2. PMID 8952966.
Gaudieri S, Leelayuwat C, Townend DC, et al. (1997). "Allelic and interlocus comparison of the PERB11 multigene family in the MHC.". Immunogenetics 45 (3): 209–16. PMID 8995188.
Pellet P, Renaud M, Fodil N, et al. (1997). "Allelic repertoire of the human MICB gene.". Immunogenetics 46 (5): 434–6. PMID 9271635.
Ando H, Mizuki N, Ota M, et al. (1997). "Allelic variants of the human MHC class I chain-related B gene (MICB).". Immunogenetics 46 (6): 499–508. PMID 9321430.
Groh V, Steinle A, Bauer S, Spies T (1998). "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells.". Science 279 (5357): 1737–40. PMID 9497295.
Visser CJ, Tilanus MG, Schaeffer V, et al. (1998). "Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles.". Tissue Antigens 51 (6): 649–52. PMID 9694358.
Steinle A, Groh V, Spies T (1998). "Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules.". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12510–5. PMID 9770516.
Groh V, Rhinehart R, Secrist H, et al. (1999). "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB.". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6879–84. PMID 10359807.
Tay GK, Hui J, Gaudieri S, et al. (2000). "PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis.". Clin. Exp. Immunol. 119 (3): 553–8. PMID 10691930.
Fischer G, Pérez-Rodríguez M, Argüello JR, et al. (2000). "Three novel MICB alleles.". Tissue Antigens 55 (2): 166–70. PMID 10746790.
Cerwenka A, Bakker AB, McClanahan T, et al. (2000). "Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.". Immunity 12 (6): 721–7. PMID 10894171.