MGST3

From Wikipedia, the free encyclopedia

Microsomal glutathione S-transferase 3

Identifiers

MGST3; GST-III

External IDs

OMIM: 604564 MGI: 1913697 HomoloGene: 3327

Gene ontology
Molecular Function:	• glutathione transferase activity • peroxidase activity • transferase activity
Cellular Component:	• membrane fraction • endoplasmic reticulum • microsome • membrane • integral to membrane
Biological Process:	• lipid metabolic process • signal transduction • antimicrobial humoral response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004528 (mRNA)
NP_004519 (protein)

NM_025569 (mRNA)
NP_079845 (protein)

Location

Chr 1: 163.87 - 163.9 Mb

Chr 1: 169.21 - 169.23 Mb

Pubmed search

[1]

[2]

Microsomal glutathione S-transferase 3, also known as MGST3, is a human gene.^[1]

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.^[1]

[edit] References

^ ^a ^b Entrez Gene: MGST3 microsomal glutathione S-transferase 3.

[edit] Further reading

Jakobsson PJ, Morgenstern R, Mancini J, et al. (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily.". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20-4. PMID 10673221.
Kobayashi K, Xin Y, Ymer SI, et al.. "Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells.". Brain Res. 1170: 129-39. doi:10.1016/j.brainres.2007.07.042. PMID 17719568.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Thameem F, Yang X, Permana PA, et al. (2003). "Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians.". Hum. Genet. 113 (4): 353-8. doi:10.1007/s00439-003-0980-y. PMID 12898215.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW (1997). "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities.". J. Biol. Chem. 272 (36): 22934-9. PMID 9278457.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.