MGAT5

From Wikipedia, the free encyclopedia

Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase

Identifiers

External IDs

OMIM: 601774 MGI: 894701 HomoloGene: 1808

Gene ontology
Molecular Function:	• transferase activity, transferring glycosyl groups • alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity
Cellular Component:	• Golgi membrane • membrane • integral to membrane
Biological Process:	• protein amino acid N-linked glycosylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002410 (mRNA)
NP_002401 (protein)

XM_912670 (mRNA)
XP_917763 (protein)

Location

Chr 2: 134.73 - 134.92 Mb

Chr 1: 129.03 - 129.31 Mb

Pubmed search

[1]

[2]

Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, also known as MGAT5, is a human gene.^[1]

This gene encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies.^[1]

[edit] References

^ ^a ^b Entrez Gene: MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase.

[edit] Further reading

Dennis JW, Granovsky M, Warren CE (2000). "Glycoprotein glycosylation and cancer progression.". Biochim. Biophys. Acta 1473 (1): 21-34. PMID 10580127.
Saito H, Nishikawa A, Gu J, et al. (1994). "cDNA cloning and chromosomal mapping of human N-acetylglucosaminyltransferase V+.". Biochem. Biophys. Res. Commun. 198 (1): 318-27. PMID 8292036.
Buckhaults P, Chen L, Fregien N, Pierce M (1997). "Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene.". J. Biol. Chem. 272 (31): 19575-81. PMID 9235963.
Park C, Jin UH, Lee YC, et al. (1999). "Characterization of UDP-N-acetylglucosamine:alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B.". Arch. Biochem. Biophys. 367 (2): 281-8. doi:10.1006/abbi.1999.1252. PMID 10395745.
Granovsky M, Fata J, Pawling J, et al. (2000). "Suppression of tumor growth and metastasis in Mgat5-deficient mice.". Nat. Med. 6 (3): 306-12. doi:10.1038/73163. PMID 10700233.
Ihara S, Miyoshi E, Ko JH, et al. (2002). "Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching.". J. Biol. Chem. 277 (19): 16960-7. doi:10.1074/jbc.M200673200. PMID 11864986.
Saito T, Miyoshi E, Sasai K, et al. (2002). "A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity.". J. Biol. Chem. 277 (19): 17002-8. doi:10.1074/jbc.M200521200. PMID 11872751.
Dosaka-Akita H, Miyoshi E, Suzuki O, et al. (2004). "Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancers.". Clin. Cancer Res. 10 (5): 1773-9. PMID 15014031.
Guo P, Zhang Y, Shen ZH, et al. (2004). "Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases.". FEBS Lett. 562 (1-3): 93-8. doi:10.1016/S0014-5793(04)00188-7. PMID 15044007.
Kim CH (2005). "Increased expression of N-acetylglucosaminyltransferase-V in human hepatoma cells by retinoic acid and 1alpha,25-dihydroxyvitamin D3.". Int. J. Biochem. Cell Biol. 36 (11): 2307-19. doi:10.1016/j.biocel.2004.04.021. PMID 15313475.
Tomiie M, Isaka S, Miyoshi E, et al. (2005). "Elevated expression of N-acetylglucosaminyltransferase V in first trimester human placenta.". Biochem. Biophys. Res. Commun. 330 (3): 999-1004. doi:10.1016/j.bbrc.2005.02.186. PMID 15809094.
Fang H, Huang W, Xu YY, et al. (2006). "Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7,721 cells.". Cell Res. 16 (1): 82-92. doi:10.1038/sj.cr.7310011. PMID 16467879.
Ishimura H, Takahashi T, Nakagawa H, et al. (2006). "N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer.". Clin. Cancer Res. 12 (8): 2506-11. doi:10.1158/1078-0432.CCR-05-1938. PMID 16638859.
Wang L, Liang Y, Li Z, et al. (2007). "Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721.". J. Cell. Biochem. 100 (1): 230-41. doi:10.1002/jcb.21071. PMID 16924681.
Li J, Wang XM, Wang Q, et al. (2007). "Down-regulation of N-acetylglucosaminyltransferase-V induces ER stress by changing glycosylation and function of GLUT1.". Arch. Biochem. Biophys. 463 (1): 102-9. doi:10.1016/j.abb.2007.03.005. PMID 17451637.
Kudo T, Nakagawa H, Takahashi M, et al. (2007). "N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma.". Mol. Cancer 6: 32. doi:10.1186/1476-4598-6-32. PMID 17488527.