MGAT4B

From Wikipedia, the free encyclopedia

Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B

Identifiers

MGAT4B; GNT-IV; GNT-IVB

External IDs

OMIM: 604561 MGI: 2143974 HomoloGene: 8611

Gene ontology
Molecular Function:	• alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity • transferase activity, transferring hexosyl groups
Cellular Component:	• membrane
Biological Process:	• carbohydrate metabolic process • N-glycan processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014275 (mRNA)
NP_055090 (protein)

NM_145926 (mRNA)
NP_666038 (protein)

Location

Chr 5: 179.16 - 179.17 Mb

Chr 11: 50.07 - 50.08 Mb

Pubmed search

[1]

[2]

Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B, also known as MGAT4B, is a human gene.^[1]

This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.^[1]

[edit] References

^ ^a ^b Entrez Gene: MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B.

[edit] Further reading

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Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. PMID 2541446.
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Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.". J. Virol. 67 (1): 150–60. PMID 8093218.
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Yoshida A, Minowa MT, Takamatsu S, et al. (1999). "A novel second isoenzyme of the human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment.". Glycoconj. J. 15 (12): 1115–23. PMID 10372966.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.