MGAT3

From Wikipedia, the free encyclopedia

Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

Identifiers

MGAT3; GNT-III; GNT3; MGC141943; MGC142278

External IDs

OMIM: 604621 MGI: 104532 HomoloGene: 31088

Gene ontology
Molecular Function:	• beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity • transferase activity, transferring glycosyl groups
Cellular Component:	• membrane • integral to membrane
Biological Process:	• protein amino acid N-linked glycosylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002409 (mRNA)
NP_002400 (protein)

NM_010795 (mRNA)
NP_034925 (protein)

Location

Chr 22: 38.18 - 38.22 Mb

Chr 15: 80 - 80.04 Mb

Pubmed search

[1]

[2]

Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, also known as MGAT3, is a human gene.^[1]

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase.

[edit] Further reading

Ihara Y, Nishikawa A, Tohma T, et al. (1993). "cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III).". J. Biochem. 113 (6): 692-8. PMID 8370666.
Kim YJ, Park JH, Kim KS, et al. (1996). "Sequence analysis of the 5'-flanking region of the gene encoding human N-acetylglucosaminyltransferase III.". Gene 170 (2): 281-3. PMID 8666260.
Koyama N, Miyoshi E, Ihara Y, et al. (1996). "Human N-acetylglucosaminyltransferase III gene is transcribed from multiple promoters.". Eur. J. Biochem. 238 (3): 853-61. PMID 8706690.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208.
Ikeda Y, Koyota S, Ihara H, et al. (2000). "Kinetic basis for the donor nucleotide-sugar specificity of beta1, 4-N-acetylglucosaminyltransferase III.". J. Biochem. 128 (4): 609-19. PMID 11011143.
Song EY, Kang SK, Lee YC, et al. (2002). "Expression of bisecting N-acetylglucosaminyltransferase-III in human hepatocarcinoma tissues, fetal liver tissues, and hepatoma cell lines of Hep3B and HepG2.". Cancer Invest. 19 (8): 799-807. PMID 11768033.
Shibukawa Y, Takahashi M, Laffont I, et al. (2003). "Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells.". J. Biol. Chem. 278 (5): 3197-203. doi:10.1074/jbc.M207870200. PMID 12427758.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sasai K, Ikeda Y, Ihara H, et al. (2003). "Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus.". J. Biol. Chem. 278 (28): 25295-301. doi:10.1074/jbc.M301913200. PMID 12716887.
Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function.". Biochem. Biophys. Res. Commun. 311 (4): 1019-25. PMID 14623284.
Isaji T, Gu J, Nishiuchi R, et al. (2004). "Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration.". J. Biol. Chem. 279 (19): 19747-54. doi:10.1074/jbc.M311627200. PMID 14998999.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Fiala M, Liu PT, Espinosa-Jeffrey A, et al. (2007). "Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin.". Proc. Natl. Acad. Sci. U.S.A. 104 (31): 12849-54. doi:10.1073/pnas.0701267104. PMID 17652175.