MGAT1

From Wikipedia, the free encyclopedia

Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

PDB rendering based on 1fo8.

Available structures: 1fo8, 1fo9, 1foa, 2am3, 2am4, 2am5, 2apc

Identifiers

Symbol(s)

MGAT1; GLCNAC-TI; GLCT1; GLYT1; GNT-1; GNT-I; MGAT

External IDs

OMIM: 160995 MGI: 96973 HomoloGene: 1804

Gene ontology
Molecular Function:	• alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity • transferase activity, transferring glycosyl groups
Cellular Component:	• Golgi membrane • Golgi apparatus • membrane • integral to membrane
Biological Process:	• carbohydrate metabolic process • aminoglycan biosynthetic process • protein amino acid N-linked glycosylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002406 (mRNA)
NP_002397 (protein)

XM_979241 (mRNA)
XP_984335 (protein)

Location

Chr 5: 180.15 - 180.18 Mb

Chr 11: 49.09 - 49.11 Mb

Pubmed search

[1]

[2]

Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, also known as MGAT1, is a human gene.^[1]

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase.

[edit] Further reading

Kumar R, Yang J, Eddy RL, et al. (1992). "Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I.". Glycobiology 2 (4): 383-93. PMID 1421759.
Kumar R, Yang J, Larsen RD, Stanley P (1991). "Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation.". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9948-52. PMID 1702225.
Hull E, Sarkar M, Spruijt MP, et al. (1991). "Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene.". Biochem. Biophys. Res. Commun. 176 (2): 608-15. PMID 1827260.
Tan J, D'Agostaro AF, Bendiak B, et al. (1995). "The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein.". Eur. J. Biochem. 231 (2): 317-28. PMID 7635144.
Yip B, Chen SH, Mulder H, et al. (1997). "Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis.". Biochem. J. 321 ( Pt 2): 465-74. PMID 9020882.
Yen CL, Stone SJ, Cases S, et al. (2002). "Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase.". Proc. Natl. Acad. Sci. U.S.A. 99 (13): 8512-7. doi:10.1073/pnas.132274899. PMID 12077311.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Saribas AS, Johnson K, Liu L, et al. (2007). "Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys 121.". Biochem. Biophys. Res. Commun. 362 (2): 381-6. doi:10.1016/j.bbrc.2007.07.199. PMID 17716624.