MFN1

From Wikipedia, the free encyclopedia

Mitofusin 1

Identifiers

MFN1; DKFZp762F247; FLJ20693; MGC41806; hfzo1; hfzo2

External IDs

OMIM: 608506 MGI: 1914664 HomoloGene: 11481

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • protein binding • GTP binding • hydrolase activity
Cellular Component:	• mitochondrion • mitochondrial outer membrane • membrane • integral to membrane • outer membrane
Biological Process:	• mitochondrial fusion • biological_process

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_033540 (mRNA)
NP_284941 (protein)

NM_024200 (mRNA)
NP_077162 (protein)

Location

n/a

Chr 3: 32.72 - 32.77 Mb

Pubmed search

[1]

[2]

Mitofusin 1, also known as MFN1, is a human gene.^[1]

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.^[1]

[edit] References

^ ^a ^b Entrez Gene: MFN1 mitofusin 1.

[edit] Further reading

Pawlikowska P, Orzechowski A (2007). "[Role of transmembrane GTPases in mitochondrial morphology and activity]". Postepy Biochem. 53 (1): 53–9. PMID 17718388.
Adams MD, Kerlavage AR, Fields C, Venter JC (1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain.". Nat. Genet. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID 8358434.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Hales KG, Fuller MT (1997). "Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase.". Cell 90 (1): 121–9. PMID 9230308.
Santel A, Fuller MT (2001). "Control of mitochondrial morphology by a human mitofusin.". J. Cell. Sci. 114 (Pt 5): 867–74. PMID 11181170.
Chung JG, Yeh KT, Wu SL, et al. (2002). "Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display.". Cancer Res. 61 (24): 8873–9. PMID 11751411.
Rojo M, Legros F, Chateau D, Lombès A (2003). "Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo.". J. Cell. Sci. 115 (Pt 8): 1663–74. PMID 11950885.
Legros F, Lombès A, Frachon P, Rojo M (2003). "Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins.". Mol. Biol. Cell 13 (12): 4343–54. doi:10.1091/mbc.E02-06-0330. PMID 12475957.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Santel A, Frank S, Gaume B, et al. (2004). "Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells.". J. Cell. Sci. 116 (Pt 13): 2763–74. doi:10.1242/jcs.00479. PMID 12759376.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L (2004). "OPA1 requires mitofusin 1 to promote mitochondrial fusion.". Proc. Natl. Acad. Sci. U.S.A. 101 (45): 15927–32. doi:10.1073/pnas.0407043101. PMID 15509649.
Cartoni R, Léger B, Hock MB, et al. (2005). "Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise.". J. Physiol. (Lond.) 567 (Pt 1): 349–58. doi:10.1113/jphysiol.2005.092031. PMID 15961417.