MFGE8

From Wikipedia, the free encyclopedia

Milk fat globule-EGF factor 8 protein

Identifiers

MFGE8; BA46; EDIL1; HsT19888; OAcGD3S

External IDs

OMIM: 602281 MGI: 102768 HomoloGene: 4334

Gene ontology
Molecular Function:	• phosphatidylserine binding • integrin binding • protein binding • phosphatidylethanolamine binding
Cellular Component:	• lipid particle • external side of plasma membrane • extrinsic to plasma membrane
Biological Process:	• phagocytosis, recognition • phagocytosis, engulfment • cell adhesion • single fertilization • positive regulation of phagocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005928 (mRNA)
NP_005919 (protein)

NM_001045489 (mRNA)
NP_001038954 (protein)

Location

Chr 15: 87.24 - 87.26 Mb

Chr 7: 79.01 - 79.02 Mb

Pubmed search

[1]

[2]

Milk fat globule-EGF factor 8 protein, also known as MFGE8, is a human gene.^[1]

[edit] References

^ Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein.

[edit] Further reading

Peterson JA, Scallan CD, Ceriani RL, Hamosh M (2002). "Structural and functional aspects of three major glycoproteins of the human milk fat globule membrane.". Adv. Exp. Med. Biol. 501: 179–87. PMID 11787681.
Larocca D, Peterson JA, Urrea R, et al. (1991). "A Mr 46,000 human milk fat globule protein that is highly expressed in human breast tumors contains factor VIII-like domains.". Cancer Res. 51 (18): 4994–8. PMID 1909932.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Couto JR, Taylor MR, Godwin SG, et al. (1996). "Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain.". DNA Cell Biol. 15 (4): 281–6. PMID 8639264.
Collins C, Nehlin JO, Stubbs JD, et al. (1997). "Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25.". Genomics 39 (1): 117–8. doi:10.1006/geno.1996.4425. PMID 9027496.
Aoki N, Ishii T, Ohira S, et al. (1997). "Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein.". Biochim. Biophys. Acta 1334 (2-3): 182–90. PMID 9101712.
Taylor MR, Couto JR, Scallan CD, et al. (1997). "Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion.". DNA Cell Biol. 16 (7): 861–9. PMID 9260929.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Giuffrida MG, Cavaletto M, Giunta C, et al. (1998). "Isolation and characterization of full and truncated forms of human breast carcinoma protein BA46 from human milk fat globule membranes.". J. Protein Chem. 17 (2): 143–8. PMID 9535276.
Newburg DS, Peterson JA, Ruiz-Palacios GM, et al. (1998). "Role of human-milk lactadherin in protection against symptomatic rotavirus infection.". Lancet 351 (9110): 1160–4. PMID 9643686.
Peterson JA, Hamosh M, Scallan CD, et al. (1998). "Milk fat globule glycoproteins in human milk and in gastric aspirates of mother's milk-fed preterm infants.". Pediatr. Res. 44 (4): 499–506. PMID 9773837.
Häggqvist B, Näslund J, Sletten K, et al. (1999). "Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid.". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8669–74. PMID 10411933.
Oshima K, Aoki N, Kato T, et al. (2002). "Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles.". Eur. J. Biochem. 269 (4): 1209–18. PMID 11856354.
Hanayama R, Tanaka M, Miwa K, et al. (2002). "Identification of a factor that links apoptotic cells to phagocytes.". Nature 417 (6885): 182–7. doi:10.1038/417182a. PMID 12000961.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lee SH, Seo GS, Park PH, et al. (2003). "Increased expression of O-acetyl disialoganglioside synthase during rat liver fibrogenesis relates to stellate cell activation.". Biochem. Biophys. Res. Commun. 303 (3): 954–61. PMID 12670504.
Rehman KS, Yin S, Mayhew BA, et al. (2004). "Human myometrial adaptation to pregnancy: cDNA microarray gene expression profiling of myometrium from non-pregnant and pregnant women.". Mol. Hum. Reprod. 9 (11): 681–700. PMID 14561811.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Reches M, Gazit E (2005). "Amyloidogenic hexapeptide fragment of medin: homology to functional islet amyloid polypeptide fragments.". Amyloid 11 (2): 81–9. PMID 15478463.