MFAP2

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Microfibrillar-associated protein 2
Identifiers
Symbol(s) MFAP2; MAGP; MAGP-1; MAGP1
External IDs OMIM: 156790 MGI: 99559 HomoloGene: 1801
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4237 17150
Ensembl ENSG00000117122 ENSMUSG00000060572
Uniprot P55001 P55002
Refseq NM_002403 (mRNA)
NP_002394 (protein)		 NM_008546 (mRNA)
NP_032572 (protein)
Location Chr 1: 17.17 - 17.18 Mb Chr 4: 140.28 - 140.29 Mb
Pubmed search [1] [2]

Microfibrillar-associated protein 2, also known as MFAP2, is a human gene.[1]

Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. This gene encodes two transcripts with two alternatively spliced 5' untranslated exons. These two transcripts contain the same 8 coding exons, and therefore, encode the same protein.[1]

[edit] References

  1. ^ a b Entrez Gene: MFAP2 microfibrillar-associated protein 2.

[edit] Further reading

  • Gibson MA, Hughes JL, Fanning JC, Cleary EG (1986). "The major antigen of elastin-associated microfibrils is a 31-kDa glycoprotein.". J. Biol. Chem. 261 (24): 11429-36. PMID 3015971. 
  • Faraco J, Bashir M, Rosenbloom J, Francke U (1995). "Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170.". Genomics 25 (3): 630-7. PMID 7759096. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Brown-Augsburger P, Broekelmann T, Rosenbloom J, Mecham RP (1996). "Functional domains on elastin and microfibril-associated glycoprotein involved in elastic fibre assembly.". Biochem. J. 318 ( Pt 1): 149-55. PMID 8761465. 
  • Finnis ML, Gibson MA (1997). "Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagen.". J. Biol. Chem. 272 (36): 22817-23. PMID 9278443. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Fujimoto N, Tajima S, Ishibashi A (2000). "Expression of microfibril-associated glycoprotein-1 (MAGP-1) in human epidermal keratinocytes.". Arch. Dermatol. Res. 292 (1): 21-6. PMID 10664011. 
  • Trask BC, Broekelmann T, Ritty TM, et al. (2001). "Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1).". Biochemistry 40 (14): 4372-80. PMID 11284693. 
  • Jensen SA, Reinhardt DP, Gibson MA, Weiss AS (2001). "Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1.". J. Biol. Chem. 276 (43): 39661-6. doi:10.1074/jbc.M104533200. PMID 11481325. 
  • Reinboth B, Hanssen E, Cleary EG, Gibson MA (2002). "Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1.". J. Biol. Chem. 277 (6): 3950-7. doi:10.1074/jbc.M109540200. PMID 11723132. 
  • Segade F, Trask BC, Broekelmann TJ, et al. (2002). "Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms.". J. Biol. Chem. 277 (13): 11050-7. doi:10.1074/jbc.M110347200. PMID 11796718. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Werneck CC, Trask BC, Broekelmann TJ, et al. (2004). "Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2.". J. Biol. Chem. 279 (22): 23045-51. doi:10.1074/jbc.M402656200. PMID 15044481. 
  • Clarke AW, Weiss AS (2004). "Microfibril-associated glycoprotein-1 binding to tropoelastin: multiple binding sites and the role of divalent cations.". Eur. J. Biochem. 271 (14): 3085-90. doi:10.1111/j.1432-1033.2004.04246.x. PMID 15233806. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Miyamoto A, Lau R, Hein PW, et al. (2006). "Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation.". J. Biol. Chem. 281 (15): 10089-97. doi:10.1074/jbc.M600298200. PMID 16492672. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414. 
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