Talk:Methandrostenolone

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[edit] Mechanism of action

"Methandrostenolone does not react strongly with the androgen receptor, instead relying on activity not mediated by the receptor for its effects."

Results reported in:
"Anabolic-androgenic steroid interaction with rat androgen receptor in vivo and in vitro: a comparative study" by B. I. Feldkoren and S. Andersson in J Steroid Biochem Mol Biol. (2005) volume 94 pages 481-487. Entrez PubMed 15876413
seem to suggest that even if methandrostenolone does not have a high affinity for the androgen receptor, it can still have effects of the androgen receptor. --JWSchmidt 14:00, 11 October 2005 (UTC)

[edit] Metabolism

"The 17α-methylation of the steroid does allow it to pass through the liver without being broken down (hence causing the aforementioned damage to the liver) allowing it to be taken orally"

This sentence is mixing together two ideas. The structure of methandrostenolone makes it less rapidly converted to inactive forms than are some other androgens. However, this does not mean that it is not broken down by the liver. The sentence in the article implies that it it because methandrostenolone is not broken down by the liver that it damages the liver. This is very unlikely. Many of the key articles on this chemical were published in German. Maybe someone who can read German and who has access to a research library can sort this out.--JWSchmidt 21:47, 11 October 2005 (UTC)

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Just curious, how has it been established 30mg per day is a "high dose"?

Answer: It doesn't sound high to me, but a check of an old PDR would determine the answer to your question. —Preceding unsigned comment added by Godofredo29 (talk • contribs) 19:04, 19 November 2007 (UTC)

[edit] Allusions to Sports Figures

The link to Bob Hoffman is not to the right Bob Hoffman. —Preceding unsigned comment added by Godofredo29 (talk • contribs) 19:01, 19 November 2007 (UTC)