Talk:Metabotropic glutamate receptor

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[edit] Error check

There is a statement in Metabotropic glutamate receptor,

"Rather than having much direct effect on postsynaptic potential, mGluRs serve to modulate the function of other receptors (Chu and Hablitz, 2000). "

I believe this to be in error. Though I cannot access the full article by Chu and Hablitz, metabotropic receptors do not modify other receptors. They usually modulate cAMP which leads to changes in ion channels - and through this they do change the postsynaptic potential. --RichG 10:33, 13 October 2005 (UTC)


You're right that it's not correct to suggest that they don't have any role in postsynaptic potential, so I'll that part of the sentence out. Their modulatory role, however, is REALLY well supported, including their ability to modify other receptors. Check it out:
  • Metabotropic glutamate receptors provide intrinsic modulation of the lamprey locomotor network. Brain Research Reviews, Volume 40, Issues 1-3, October 2002, Pages 9-18 Abdeljabbar El Manira, Petronella Kettunen, Dietmar Hess and Patrik Krieger
  • Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A2A and dopamine D2 receptors. Neuroscience Letters, Volume 324, Issue 2, 17 May 2002, Pages 154-158 Zaida Díaz-Cabiale, Meritxell Vivó, Alberto Del Arco, William T. O'Connor, Michael K. Harte, Christa E. Müller, Emili Martínez, Patrizia Popoli, Kjell Fuxe and Sergi Ferré
  • Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience, Volume 106, Issue 3, 27 September 2001, Pages 579-587. A. Pisani, P. Gubellini, P. Bonsi, F. Conquet, B. Picconi, D. Centonze, G. Bernardi and P. Calabresi
  • Activation of metabotropic glutamate receptor 1 inhibits glutamatergic transmission in the substantia nigra pars reticulata. Neuroscience, Volume 105, Issue 4, 22 August 2001, Pages 881-889. M. Wittmann, G. W. Hubert, Y. Smith and P. J. Conn

plus, these quotes from articles I'll have listed in the references:

  • "The mGluRs modulate excitatory synaptic transmission in various regions of the brain (Endoh, 2004)"
  • "Glutamate ... activates both ionotropic and metabotropic glutamate receptors (mGluRs). The former is involved in fast synaptic transmission whereas the latter play a modulatory role (Chu and Hablitz, 2000)."
  • "[D]istinct functional roles for group I mGluR subtypes have been demonstrated for medium spiny neurons, either in synaptic plasticity or in the modulation of NMDA receptor activity (Bonsi, 2005)."
With this and the fact that I'll take out the "much role in postsynaptic potential" part, would you say it's fair to remove the 'dubious' tag? --Delldot 20:28, 13 October 2005 (UTC)
  • Ok, good work! Apparently mGluR do indeed modulate other receptors. I appreciate the lesson. This is cutting edge stuff. --RichG 01:45, 14 October 2005 (UTC)


[edit] Broken link?

Does this link work for anyone else? Should we remove it or replace it?

Thanks, delldot | talk 21:00, 14 January 2007 (UTC)

Oh, never mind, I got to it through the web archive. [1] delldot | talk 22:09, 25 January 2007 (UTC)