Methylthioribulose 1-phosphate dehydratase

From Wikipedia, the free encyclopedia

In enzymology, a methylthioribulose 1-phosphate dehydratase (EC 4.2.1.109) is an enzyme that catalyzes the chemical reaction

S-methyl-5-thio-D-ribulose 1-phosphate 5-(methylthio)-2,3-dioxopentyl phosphate + H₂O

Hence, this enzyme has one substrate, S-methyl-5-thio-D-ribulose 1-phosphate, and two products, 5-(methylthio)-2,3-dioxopentyl phosphate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is S-methyl-5-thio-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]. Other names in common use include 1-PMT-ribulose dehydratase, and S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase. This enzyme participates in methionine metabolism.

[edit] References

• IUBMB entry for 4.2.1.109
• BRENDA references for 4.2.1.109 (Recommended.)
• PubMed references for 4.2.1.109
• PubMed Central references for 4.2.1.109
• Google Scholar references for 4.2.1.109
• Furfine ES, Abeles RH (1988). "Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae". J. Biol. Chem. 263: 9598–606. PMID 2838472. 
• Wray JW, Abeles RH (1995). "The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases". J. Biol. Chem. 270: 3147–53. PMID 7852397. 

[edit] External links

• IUBMB entry for 4.2.1.109

• KEGG entry for 4.2.1.109

• BRENDA entry for 4.2.1.109

• NiceZyme view of 4.2.1.109

• EC2PDB: PDB structures for 4.2.1.109

• PRIAM entry for 4.2.1.109

• PUMA2 entry for 4.2.1.109

• IntEnz: Integrated Enzyme entry for 4.2.1.109

• MetaCyc entry for 4.2.1.109

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043809: methylthioribulose 1-phosphate dehydratase

• AMIGO entry for GO code 0043809: methylthioribulose 1-phosphate dehydratase